Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24112192 | 0.96 | GRIN2B (0.57) | GRIN2BGRIN2CJAK3CDK4SPR | |
| SCHEMBL31341770 | 0.90 | GRIN2B (0.54) | GRIN2BGRIN2CJAK3CDK4HPGD | |
| SCHEMBL21466075 | 0.84 | GRIN2B (0.63) | GRIN2BGRIN2CJAK3CDK4SPR | |
| SCHEMBL24740823 | 0.83 | GRIN2B (0.58) | GRIN2BGRIN2CJAK3CDK4SPR | |
| SCHEMBL21225326 | 0.79 | GRIN2B (0.52) | GRIN2BGRIN2CJAK3CDK4SPR | |
| SCHEMBL24338392 | 0.79 | GRIN2B (0.78) | GRIN2BGRIN2CJAK3CDK4 | |
| SCHEMBL25852386 | 0.78 | GRIN2B (0.51) | GRIN2BGRIN2CJAK3CDK4BUB1 | |
| SCHEMBL23835781 | 0.78 | GRIN2B (0.63) | GRIN2BGRIN2CJAK3CDK4SPR | |
| SCHEMBL30832396 | 0.78 | GRIN2B (0.50) | GRIN2BGRIN2CJAK3CDK4SPR | |
| SCHEMBL22975107 | 0.77 | GRIN2B (0.46) | GRIN2BGRIN2CJAK3SPRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252644-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. (US) | 2021-12-16 | — | — | WO | disclosed |