Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.58 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.58 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | IL1B | P01584 | 1/20 | 0.58 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.58 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.46 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL283824 | 1.00 | CRBN (0.58) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL283159 | 0.92 | CRBN (0.60) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL12638455 | 0.92 | CRBN (0.47) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL282617 | 0.92 | CRBN (0.56) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL282665 | 0.92 | CRBN (0.59) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL287793 | 0.90 | CRBN (0.54) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL282730 | 0.90 | CRBN (0.55) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL328542 | 0.89 | CRBN (0.54) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL282762 | 0.88 | CRBN (0.58) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL328502 | 0.88 | CRBN (0.58) | CRBNDDB1TNFIL1BIKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3925609-A1 | METHODS OF TREATING MULTIPLE MYELOMA WITH IMMUNOMODULATORY COMPOUNDS IN COMBINATION WITH ANTIBODIES | Celgene Corporation (US) | 2021-12-22 | — | — | EP | disclosed |