Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.58 |
| ▸ | DDB1 | Q16531 | 14/20 | 0.58 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | IL1B | P01584 | 1/20 | 0.58 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.58 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282665 | 0.93 | CRBN (0.59) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL283159 | 0.92 | CRBN (0.60) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL282762 | 0.92 | CRBN (0.58) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL282990 | 0.90 | CRBN (0.56) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL328464 | 0.90 | CRBN (0.56) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL24113869 | 0.88 | CRBN (0.58) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL283824 | 0.88 | CRBN (0.58) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL283343 | 0.88 | CRBN (0.54) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL282730 | 0.88 | CRBN (0.55) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL286218 | 0.88 | CRBN (0.66) | CRBNDDB1TNFIL1BIKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428513-A1 | 5-substituted quinazolinone derivatives as anti-cancer agents | Celgene Corporation (US) | 2012-03-14 | — | — | EP | disclosed |
| EP-2420497-A1 | 5-substituted quinazolinone derivatives as anti-cancer agents | CELGENE CORPORATION (US) | 2012-02-22 | — | — | EP | disclosed |
| WO-2008039489-A2 | 5-SUBSTITUTED QUINAZOLINONE DERIVATIVES AS ANTITUMOR AGENTS | CELGENE CORPORATION (US) | 2008-04-03 | — | — | WO | disclosed |