⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2757922 | 0.79 | — | — | |
| SCHEMBL15097744 | 0.76 | POLB (0.37) | — | |
| SCHEMBL1289839 | 0.74 | — | — | |
| SCHEMBL6676461 | 0.74 | — | — | |
| SCHEMBL22778278 | 0.74 | — | — | |
| SCHEMBL132657 | 0.74 | DGAT1 (0.42) | — | |
| SCHEMBL6792199 | 0.74 | — | — | |
| SCHEMBL28978930 | 0.74 | — | — | |
| SCHEMBL7815595 | 0.72 | EPHX1 (0.42) | — | |
| Ammonia Solution, Strong SCHEMBL9998482 | 0.72 | DGAT1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11160783-B2 | Multikinase inhibitors for use in the treatment of cancer | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2021-11-02 | — | — | US | disclosed |
| US-20180353468-A1 | MULTIKINASE INHIBITORS FOR USE IN THE TREATMENT OF CANCER | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-12-13 | — | — | US | disclosed |
| EP-2182941-B1 | MULTIKINASE INHIBITORS FOR USE IN THE TREATMENT OF CANCER | EISAI R&D MAN CO LTD (JP) | 2018-02-28 | — | — | EP | disclosed |
| CN-104662082-B | High melt strength polypropylene of improved quality | 北欧化工公司 | 2017-04-12 | — | — | CN | disclosed |
| CN-104204115-B | The extrusion coated polymeric layer that coefficient of friction reduces | 北欧化工公司 | 2016-11-23 | — | — | CN | disclosed |
| EP-2794603-B1 | [1,2,4]TRIAZOLOPYRIDINES AND THEIR USE AS PHOSPODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-06-15 | — | — | EP | disclosed |
| US-9181248-B2 | [1,2,4]triazolopyridines and their use as phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2015-11-10 | — | — | US | disclosed |
| US-20150182496-A1 | MULTIKINASE INHIBITORS FOR USE IN THE TREATMENT OF CANCER | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-07-02 | — | — | US | disclosed |
| US-20150105420-A1 | [1,2,4]TRIAZOLOPYRIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | UNION therapeutics A/S (DK) | 2015-04-16 | — | — | US | disclosed |
| US-8940761-B2 | [1,2,4]triazolopyridines and their use as phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2015-01-27 | — | — | US | disclosed |
| EP-2181104-B1 | ZEARALENONE MACROLIDE DERIVATIVES AND USES OF THE SAME | EISAI R&D MAN CO LTD (JP) | 2011-09-07 | — | — | EP | disclosed |
| US-7858388-B2 | MS based peptide and protein sequencing via reactions of lysine residues with peroxycarbonate compounds | VANDERBILT UNIVERSITY (US) | 2010-12-28 | — | — | US | disclosed |
| EP-2182941-A2 | MULTIKINASE INHIBITORS FOR USE IN THE TREATMENT OF CANCER | Eisai R&D Management Co., Ltd. (JP) | 2010-05-12 | — | — | EP | disclosed |
| EP-2181104-A1 | ZEARALENONE MACROLIDE DERIVATIVES AND USES OF THE SAME | Eisai R&D Management Co., Ltd. (JP) | 2010-05-05 | — | — | EP | disclosed |
| US-20090082313-A1 | Multikinase Inhibitors for Use in the Treatment of Cancer | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-03-26 | — | — | US | disclosed |
| US-20090048333-A1 | Zearalenone Macrolide Derivatives and Uses of the Same | EISAI CO., LTD. (JP) | 2009-02-19 | — | — | US | disclosed |
| WO-2009015368-A2 | MULTIKINASE INHIBITORS FOR USE IN THE TREATMENT OF CANCER | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-01-29 | — | — | WO | disclosed |
| WO-2009015363-A1 | ZEARALENONE MACROLIDE DERIVATIVES AND USES OF THE SAME | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-01-29 | — | — | WO | disclosed |
| US-20070249056-A1 | Peptide and Protein Fragmentation by Lysine Residue Originated Reactions | VANDERBILT UNIVERSITY | 2007-10-25 | — | — | US | disclosed |
| WO-2005037857-A2 | METHOD OF PROTEIN ANALYSIS BY MALDI USING PROTEIN FRAGMENTATION WITH PEROXYCARBONATES | VANDERBILT UNIVERSITY (US) | 2005-04-28 | — | — | WO | disclosed |