Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TYR | P14679 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16639680 | 0.94 | NPC1 (0.38) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL18866930 | 0.83 | NPC1 (0.39) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL19841535 | 0.78 | NPC1 (0.41) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL22661833 | 0.78 | NPC1 (0.41) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL19841674 | 0.78 | NPC1 (0.34) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL20880273 | 0.75 | NQO2 (0.43) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL23739009 | 0.75 | NQO2 (0.43) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL12938128 | 0.73 | NPC1 (0.50) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL2706284 | 0.73 | NPC1 (0.50) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL13071138 | 0.71 | AKR1C3 (0.41) | NPC1RAB9AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3925627-A1 | DRUG-CONJUGATES AND USES THEREOF | Concortis Biosystems, Corp (US) | 2021-12-22 | — | — | EP | disclosed |