Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24118264 | 0.90 | IDO1 (0.52) | IDO1BCHEMAOBKLK7MMP1 | |
| SCHEMBL21503950 | 0.77 | IDO1 (0.44) | IDO1BCHENPC1RAB9AMAOB | |
| SCHEMBL23593346 | 0.73 | KLK7 (0.41) | IDO1SMN1; SMN2KLK7L3MBTL1POLB | |
| SCHEMBL24117950 | 0.73 | KLK7 (0.41) | IDO1SMN1; SMN2KLK7L3MBTL1POLB | |
| SCHEMBL23592415 | 0.73 | KLK7 (0.41) | IDO1SMN1; SMN2KLK7L3MBTL1POLB | |
| SCHEMBL23593353 | 0.71 | IDO1 (0.44) | IDO1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL24118300 | 0.70 | IDO1 (0.55) | IDO1SMN1; SMN2KLK7 | |
| SCHEMBL24118142 | 0.70 | SIRT2 (0.45) | IDO1SMN1; SMN2 | |
| SCHEMBL24118287 | 0.69 | SMN1; SMN2 (0.47) | IDO1NPC1RAB9ASMN1; SMN2KLK7 | |
| SCHEMBL21504255 | 0.69 | IDO1 (0.81) | IDO1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | IDO1, IDO2, TPH1 | IDO1 1/4885BCHE 120/4885NPC1 1240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.