Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 18/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 10/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.43 |
| ▸ | FLT3 | P36888 | 6/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3492909 | 0.84 | CSF1R (0.57) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL16028718 | 0.74 | CSF1R (0.59) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL23888703 | 0.73 | PIM1 (0.51) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL30086972 | 0.73 | PIM1 (0.51) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL16045598 | 0.73 | CSF1R (0.57) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL21425566 | 0.73 | CSF1R (0.51) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL19338421 | 0.73 | CSF1R (0.59) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL21425565 | 0.71 | CSF1R (0.53) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL16046299 | 0.71 | CSF1R (0.57) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL29736796 | 0.71 | CSF1R (0.52) | CSF1RPDGFRAPDGFRBFLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365752-A1 | CYCLOPROPANE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | Deciphera Pharmaceuticals, Llc (US) | 2011-09-21 | — | — | EP | disclosed |
| WO-2010051373-A1 | CYCLOPROPANE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2010-05-06 | — | — | WO | disclosed |