Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.50 |
| ▸ | RAB9A | P51151 | 9/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.42 |
| ▸ | RELA | Q04206 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24124786 | 0.86 | KMT2A (0.46) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL24124211 | 0.86 | NPC1 (0.34) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL24124872 | 0.81 | RAB9A (0.46) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL24124166 | 0.80 | HDAC8 (0.48) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL8460319 | 0.80 | MEN1 (0.52) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL24125211 | 0.80 | MAPT (0.43) | NPC1RAB9AKMT2AMAPTMEN1 | |
| SCHEMBL24124175 | 0.79 | USP7 (0.52) | RAB9AMAPTKDM4EHTTGAA | |
| SCHEMBL24124799 | 0.79 | MAPT (0.60) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL24124212 | 0.78 | MAPT (0.61) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL9147195 | 0.77 | MEN1 (0.51) | NPC1RAB9AKMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021257544-A1 | SOX11 INHIBITORS FOR TREATING MANTLE CELL LYMPHOMA | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2021-12-23 | — | — | WO | disclosed |