Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | AR | P10275 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CASR | P41180 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5009001 | 0.80 | HPGD (0.70) | HPGDTSHRRAB9ALMNANPC1 | |
| SCHEMBL11707322 | 0.79 | HTT (0.58) | HPGDTSHRLMNASMN1; SMN2MAPT | |
| SCHEMBL11201897 | 0.79 | HTT (0.55) | HPGDTSHRLMNASMN1; SMN2MAPT | |
| SCHEMBL569213 | 0.78 | NPSR1 (0.59) | TSHRRAB9ALMNANPC1AR | |
| SCHEMBL18046824 | 0.78 | HPGD (0.64) | HPGDTSHRRAB9ALMNANPC1 | |
| SCHEMBL18584288 | 0.78 | HPGD (0.64) | HPGDTSHRRAB9ALMNANPC1 | |
| SCHEMBL3144343 | 0.78 | HPGD (0.64) | HPGDTSHRRAB9ALMNANPC1 | |
| SCHEMBL15595665 | 0.78 | POLB (0.69) | HPGDTSHRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5717617 | 0.78 | HTT (0.53) | HPGDTSHRRAB9ALMNASMN1; SMN2 | |
| SCHEMBL4944465 | 0.78 | MAPT (0.53) | HPGDTSHRLMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021257828-A1 | SUBSTITUTED THIENOPYRIMIDINES THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, LLC (US) | 2021-12-23 | — | — | WO | disclosed |