Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC6 | Q9Y210 | 4/20 | 0.59 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.59 |
| ▸ | TRPC7 | Q9HCX4 | 1/20 | 0.59 |
| ▸ | SLC9A3 | P48764 | 12/20 | 0.47 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2412453 | 0.89 | TRPC6 (0.58) | TRPC6TRPC3TRPC7SLC9A3CYP2D6 | |
| SCHEMBL2410065 | 0.89 | TRPC6 (0.73) | TRPC6TRPC3TRPC7SLC9A3CYP2D6 | |
| SCHEMBL2408820 | 0.89 | TRPC6 (0.73) | TRPC6TRPC3TRPC7SLC9A3CYP2D6 | |
| SCHEMBL12363380 | 0.89 | TRPC6 (0.73) | TRPC6TRPC3TRPC7SLC9A3CYP2D6 | |
| SCHEMBL2413989 | 0.88 | TRPC6 (0.58) | TRPC6TRPC3TRPC7SLC9A3CYP2D6 | |
| SCHEMBL2408285 | 0.87 | TRPC6 (0.57) | TRPC6TRPC3TRPC7SLC9A3CYP2D6 | |
| SCHEMBL2410217 | 0.85 | TRPC6 (0.80) | TRPC6TRPC3TRPC7SLC9A3CYP2D6 | |
| SCHEMBL2409758 | 0.85 | TRPC6 (0.80) | TRPC6TRPC3TRPC7SLC9A3CYP2D6 | |
| SCHEMBL12363389 | 0.84 | TRPC6 (0.70) | TRPC6TRPC3TRPC7SLC9A3CYP2D6 | |
| SCHEMBL12290635 | 0.81 | TRPC6 (0.52) | TRPC6TRPC3TRPC7SLC9A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130131034-A1 | DERIVATIVES OF AMINOINDANES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS | SANOFI (FR) | 2013-05-23 | — | — | US | claimed |
| EP-2542524-A1 | DERIVATIVES OF AMINOINDANES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS | SANOFI (FR) | 2013-01-09 | — | — | EP | claimed |
| EP-2368876-A1 | Derivatives of aminoindanes, their preparation and their application in therapeutics | SANOFI (FR) | 2011-09-28 | — | — | EP | claimed |
| US-20130131034-A1 | DERIVATIVES OF AMINOINDANES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS | SANOFI (FR) | 2013-05-23 | — | — | US | disclosed |
| US-20130131034-A1 | DERIVATIVES OF AMINOINDANES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS | SANOFI (FR) | 2013-05-23 | — | — | US | disclosed |
| US-20130131034-A1 | DERIVATIVES OF AMINOINDANES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS | SANOFI (FR) | 2013-05-23 | — | — | US | disclosed |
| EP-2542524-A1 | DERIVATIVES OF AMINOINDANES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS | SANOFI (FR) | 2013-01-09 | — | — | EP | disclosed |
| EP-2368876-A1 | Derivatives of aminoindanes, their preparation and their application in therapeutics | SANOFI (FR) | 2011-09-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131034-A1 | DERIVATIVES OF AMINOINDANES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS | ANXA2, ANXA3, ADM2 | TRPC6 3080/4885TRPC3 2333/4885TRPC7 3887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.