Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 10/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21851189 | 0.79 | KDR (0.39) | KDRSIGMAR1CXCR4USP2HRH3 | |
| SCHEMBL21850946 | 0.76 | KCNJ1 (0.56) | KDRSIGMAR1CXCR4USP2KCNJ1 | |
| SCHEMBL21851192 | 0.76 | KCNJ1 (0.40) | KDRSIGMAR1CXCR4USP2HRH3 | |
| SCHEMBL21850808 | 0.76 | KCNJ1 (0.55) | KDRSIGMAR1CXCR4USP2HRH3 | |
| SCHEMBL21850936 | 0.76 | KCNJ1 (0.41) | KDRSIGMAR1CXCR4USP2HRH3 | |
| SCHEMBL21851187 | 0.73 | KCNJ1 (0.42) | KDRSIGMAR1CXCR4USP2HRH3 | |
| SCHEMBL21850916 | 0.73 | KCNJ1 (0.43) | KDRSIGMAR1CHRM2CHRM1KCNJ1 | |
| SCHEMBL21850933 | 0.73 | KCNJ1 (0.45) | KDRSIGMAR1CXCR4USP2KCNJ1 | |
| SCHEMBL21850937 | 0.71 | CXCR4 (0.40) | KDRSIGMAR1CXCR4USP2HRH3 | |
| SCHEMBL21850868 | 0.69 | SIGMAR1 (0.41) | SIGMAR1CXCR4HRH3MEN1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3929194-A1 | SUBSTITUTED NITROGEN CONTAINING COMPOUNDS | Bristol-Myers Squibb Company (US) | 2021-12-29 | — | — | EP | disclosed |