Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | FLT1 | P17948 | 1/20 | 0.30 |
| ▸ | FLT4 | P35916 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22434676 | 0.84 | HSD17B10 (0.36) | ERN1MAP3K14TRPV4MAPTSMN1; SMN2 | |
| SCHEMBL24136160 | 0.74 | HTR2C (0.39) | ALDH1A1HPGD | |
| SCHEMBL20504688 | 0.73 | HASPIN (0.34) | — | |
| SCHEMBL13256218 | 0.66 | ERN1 (0.45) | ERN1MAP3K14TRPV4MAPT | |
| SCHEMBL24136206 | 0.64 | CYP19A1 (0.35) | MAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL24136189 | 0.64 | MEN1 (0.35) | MAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL24136192 | 0.64 | — | — | |
| SCHEMBL22434675 | 0.63 | PDE2A (0.37) | SMN1; SMN2L3MBTL1ALDH1A1HPGD | |
| SCHEMBL26913230 | 0.62 | RHEB (0.33) | ERN1TRPV4SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL17452831 | 0.62 | HSD17B10 (0.41) | MAPTSMN1; SMN2L3MBTL1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3928836-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2021-12-29 | — | — | EP | disclosed |