Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 12/20 | 0.68 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.47 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280368 | 0.85 | CHUK (0.51) | CHUKLRRK2ROCK2ROCK1CDC42BPA | |
| SCHEMBL22280369 | 0.81 | CHUK (0.54) | CHUKLRRK2ROCK2ROCK1CDC42BPA | |
| SCHEMBL22280265 | 0.80 | CHUK (0.46) | CHUKLRRK2ROCK2ROCK1CDC42BPA | |
| SCHEMBL31095312 | 0.80 | CHUK (0.71) | CHUKLRRK2ROCK2ROCK1CDC42BPA | |
| SCHEMBL19010829 | 0.80 | CHUK (0.71) | CHUKLRRK2ROCK2ROCK1CDC42BPA | |
| SCHEMBL20343974 | 0.80 | CHUK (0.65) | CHUKLRRK2IKBKB | |
| SCHEMBL20555173 | 0.78 | LRRK2 (0.50) | CHUKLRRK2HSP90AB1HSP90AA1XDH | |
| SCHEMBL19010828 | 0.77 | CHUK (0.43) | CHUKLRRK2ROCK2ROCK1CDC42BPA | |
| SCHEMBL20344046 | 0.76 | XDH (0.42) | CHUKLRRK2XDH | |
| SCHEMBL20344047 | 0.76 | CHUK (0.74) | CHUKLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11208412-B2 | Pyrrolo-pyrimidine derivative compound, preparation method therefor, and pharmaceutical composition comprising same compound as effective ingredient for preventing or treating protein kinase-related disease | DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION (KR) | 2021-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11208412-B2 | Pyrrolo-pyrimidine derivative compound, preparation method therefor, and pharmaceutical composition comprising same compound as effective ingredient for preventing or treating protein kinase-related disease | LRRK2, WEE1, WEE2 | CHUK 653/4885LRRK2 1/4885ROCK2 1138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.