Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 12/20 | 0.57 |
| ▸ | CDC7 | O00311 | 3/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.57 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 4/20 | 0.57 |
| ▸ | CDK7 | P50613 | 12/20 | 0.53 |
| ▸ | AKT1 | P31749 | 2/20 | 0.51 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24137786 | 0.91 | JAK2 (0.57) | CDK2CDC7CCNE1DBF4JAK2 | |
| SCHEMBL25936215 | 0.88 | JAK2 (0.50) | CDK2CDC7CCNE1DBF4JAK2 | |
| SCHEMBL24137915 | 0.88 | JAK2 (0.57) | CDK2CDC7CCNE1DBF4JAK2 | |
| SCHEMBL24137727 | 0.85 | JAK2 (0.52) | CDK2CDC7CCNE1DBF4JAK2 | |
| SCHEMBL25936076 | 0.85 | JAK2 (0.48) | CDK2CDC7CCNE1DBF4JAK2 | |
| SCHEMBL24137846 | 0.85 | CDK7 (0.52) | CDK2CDC7CCNE1DBF4JAK2 | |
| SCHEMBL24137841 | 0.84 | JAK2 (0.61) | CDK2CDC7JAK2CDK7AKT1 | |
| SCHEMBL24137534 | 0.81 | JAK2 (0.61) | CDK2CDC7CCNE1DBF4JAK2 | |
| SCHEMBL21318857 | 0.80 | JAK2 (0.56) | CDK2CDC7JAK2AKT1ROCK2 | |
| SCHEMBL24137563 | 0.80 | CCNC (0.61) | CDK2CDC7CCNE1DBF4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234935-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2023-07-27 | — | — | US | disclosed |
| WO-2021263129-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2021-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234935-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | PACSIN2, MAP3K20, PHKG1 | CDK2 68/4885CDC7 446/4885CCNE1 771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.