Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Buprenorphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 known ✓ | P41145 | 14/20 | 1.00 |
| ▸ | OPRM1 known ✓ | P35372 | 9/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 10/20 | 1.00 |
| ▸ | OPRL1 | P41146 | 5/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Buprenorphine SCHEMBL24437359 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL24145260 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL24846187 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL24437360 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL23647314 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL24145377 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL24171581 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL23629525 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL24145658 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL23702715 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021262763-A1 | OPIOID RECEPTOR MODULATOR AND USE THEREOF | ARRIBA BIOPHARMA, INC. (US) | 2021-12-30 | — | — | WO | disclosed |