Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | FER | P16591 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | MARK3 | P27448 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | CLK2 | P49760 | 1/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.52 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.52 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13655149 | 0.81 | CHEK1 (0.68) | CHEK1CDK7 | |
| SCHEMBL14338764 | 0.78 | HSD17B10 (0.52) | AURKBDCLK1PRKD3MAP4K4CHEK2 | |
| SCHEMBL2872738 | 0.78 | JAK2 (0.57) | LRRK2AURKBFLT3JAK2ALDH1A1 | |
| SCHEMBL578335 | 0.75 | SMN1; SMN2 (0.70) | CNR1CNR2ALDH1A1NCF1 | |
| SCHEMBL1593369 | 0.74 | LRRK2 (0.52) | LRRK2CNR1CNR2AURKBCSF1R | |
| SCHEMBL13655139 | 0.74 | CHEK1 (0.75) | CHEK1CDK7 | |
| SCHEMBL883286 | 0.74 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL16025480 | 0.74 | LRRK2 (0.74) | LRRK2 | |
| SCHEMBL17160816 | 0.73 | SMN1; SMN2 (0.68) | CNR1CNR2ALDH1A1NCF1 | |
| SCHEMBL6818232 | 0.73 | SMN1; SMN2 (0.68) | CNR1CNR2ALDH1A1NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021262684-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | PMV PHARMACEUTICALS, INC. (US) | 2021-12-30 | — | — | WO | disclosed |