Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | POLRMT | O00411 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24149793 | 0.94 | POLRMT (0.32) | POLRMTCYP3A4CYP2C9RIPK1 | |
| SCHEMBL30269866 | 0.91 | TMPRSS2 (0.38) | KRAS | |
| SCHEMBL24149405 | 0.91 | KRAS (0.30) | KRAS | |
| SCHEMBL24148992 | 0.91 | TMPRSS2 (0.38) | KRAS | |
| SCHEMBL18667331 | 0.90 | CYP3A4 (0.39) | KRASCYP3A4CYP2C9RIPK1 | |
| SCHEMBL20878382 | 0.90 | CYP3A4 (0.39) | KRASCYP3A4CYP2C9RIPK1 | |
| SCHEMBL18636467 | 0.90 | CYP3A4 (0.39) | KRASCYP3A4CYP2C9RIPK1 | |
| SCHEMBL18636470 | 0.90 | CYP3A4 (0.39) | KRASCYP3A4CYP2C9RIPK1 | |
| SCHEMBL22096278 | 0.90 | CYP3A4 (0.39) | KRASCYP3A4CYP2C9RIPK1 | |
| SCHEMBL18666874 | 0.90 | CYP3A4 (0.39) | KRASCYP3A4CYP2C9RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021262826-A2 | 1'-CYANO NUCLEOSIDE ANALOGS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2021-12-30 | — | — | WO | disclosed |