Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.60 |
| ▸ | CNR2 | P34972 | 2/20 | 0.55 |
| ▸ | CNR1 | P21554 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | GRM5 | P41594 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.47 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2593387 | 0.98 | HSD11B1 (0.63) | HSD11B1CNR2CNR1ALDH1A1NPC1 | |
| SCHEMBL4779 | 0.94 | HSD11B1 (0.52) | HSD11B1CNR2CNR1HPGDGRM5 | |
| SCHEMBL3508899 | 0.88 | HSD11B1 (0.61) | HSD11B1CNR2CNR1HPGDGRM5 | |
| SCHEMBL3508894 | 0.88 | HSD11B1 (0.61) | HSD11B1CNR2CNR1HPGDGRM5 | |
| SCHEMBL19445811 | 0.87 | HSD11B1 (0.71) | HSD11B1CNR2CNR1HPGDGRM5 | |
| SCHEMBL6083575 | 0.87 | CD38 (0.49) | HSD11B1CNR2HPGDGRM5ALDH1A1 | |
| SCHEMBL6083571 | 0.87 | CD38 (0.49) | HSD11B1CNR2HPGDGRM5ALDH1A1 | |
| SCHEMBL24150891 | 0.87 | SMYD3 (0.49) | HSD11B1CNR2HPGDGRM5ALDH1A1 | |
| SCHEMBL24149920 | 0.87 | CNR2 (0.59) | HSD11B1CNR2CNR1HPGDGRM5 | |
| SCHEMBL24150078 | 0.86 | HSD11B1 (0.53) | HSD11B1CNR2CNR1GRM5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230046427-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | PMV PHARMACEUTICALS, INC. | 2023-02-16 | — | — | US | disclosed |
| WO-2021262596-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT P53 FUNCTION | PMV PHARMACEUTICALS, INC. (US) | 2021-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230046427-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | TP53, TP53BP1, HRAS | HSD11B1 3658/4885CNR2 4797/4885CNR1 4696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.