Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.53 |
| ▸ | JAK1 | P23458 | 3/20 | 0.53 |
| ▸ | BTK | Q06187 | 8/20 | 0.44 |
| ▸ | PLCG1 | P19174 | 2/20 | 0.44 |
| ▸ | ITK | Q08881 | 4/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30190759 | 1.00 | JAK3 (0.53) | JAK3JAK1BTKPLCG1ITK | |
| SCHEMBL24150512 | 0.89 | KMO (0.49) | JAK3JAK1BTKPLCG1ITK | |
| SCHEMBL24150511 | 0.88 | JAK3 (0.45) | JAK3JAK1BTKPLCG1ITK | |
| SCHEMBL24150191 | 0.84 | JAK3 (0.51) | JAK3JAK1BTKPLCG1ITK | |
| SCHEMBL30190875 | 0.84 | JAK3 (0.51) | JAK3JAK1BTKPLCG1ITK | |
| SCHEMBL30190549 | 0.84 | EHMT2 (0.48) | JAK3JAK1BTKITKJAK2 | |
| SCHEMBL24150195 | 0.84 | EHMT2 (0.48) | JAK3JAK1BTKITKJAK2 | |
| SCHEMBL30190722 | 0.76 | JAK3 (0.51) | JAK3JAK1BTKPLCG1ITK | |
| SCHEMBL24150517 | 0.76 | JAK3 (0.51) | JAK3JAK1BTKPLCG1ITK | |
| SCHEMBL24150854 | 0.73 | CCNC (0.47) | JAK3JAK1JAK2TYK2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11926632-B2 | Methods and compounds for restoring mutant p53 function | PMV PHARMACEUTICALS, INC. (US) | 2024-03-12 | — | — | US | disclosed |
| US-20230046427-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | PMV PHARMACEUTICALS, INC. | 2023-02-16 | — | — | US | disclosed |
| US-20230046427-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | PMV PHARMACEUTICALS, INC. | 2023-02-16 | — | — | US | disclosed |
| WO-2021262596-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT P53 FUNCTION | PMV PHARMACEUTICALS, INC. (US) | 2021-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230046427-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | TP53, TP53BP1, HRAS | JAK3 4427/4885JAK1 4667/4885BTK 4194/4885 |
| US-11926632-B2 | Methods and compounds for restoring mutant p53 function | TP53, TP53BP1, HRAS | JAK3 4427/4885JAK1 4667/4885BTK 4194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.