Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 5/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | MAP2K7 | O14733 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 8/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 2/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | BLK | P51451 | 1/20 | 0.40 |
| ▸ | BMX | P51813 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30190678 | 0.82 | DHFR (0.60) | GAKJAK3JAK1MAP2K7AURKA | |
| SCHEMBL24150553 | 0.82 | DHFR (0.60) | GAKJAK3JAK1MAP2K7AURKA | |
| SCHEMBL30190523 | 0.77 | JAK3 (0.58) | GAKJAK3JAK1MAP2K7AURKA | |
| SCHEMBL24151662 | 0.77 | JAK3 (0.58) | GAKJAK3JAK1MAP2K7AURKA | |
| SCHEMBL30190844 | 0.76 | MAP4K4 (0.51) | JAK3JAK1MAP2K7AURKABTK | |
| SCHEMBL24150188 | 0.76 | MAP4K4 (0.51) | JAK3JAK1MAP2K7AURKABTK | |
| SCHEMBL30190650 | 0.76 | JAK3 (0.55) | GAKJAK3JAK1MAP2K7AURKA | |
| SCHEMBL24150339 | 0.76 | JAK3 (0.55) | GAKJAK3JAK1MAP2K7AURKA | |
| SCHEMBL24150360 | 0.74 | BTK (0.53) | GAKJAK3JAK1MAP2K7AURKA | |
| SCHEMBL30190703 | 0.74 | BTK (0.53) | GAKJAK3JAK1MAP2K7AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021262596-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT P53 FUNCTION | PMV PHARMACEUTICALS, INC. (US) | 2021-12-30 | — | — | WO | disclosed |