Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.34 |
| ▸ | POLRMT | O00411 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23047667 | 0.90 | DOT1L (0.33) | DOT1LPOLRMT | |
| SCHEMBL22355532 | 0.87 | BTN3A1 (0.34) | DOT1LPOLRMTRIPK1 | |
| SCHEMBL23047641 | 0.87 | CYP3A4 (0.37) | RIPK1 | |
| SCHEMBL24058411 | 0.86 | DOT1L (0.32) | DOT1LPOLRMTRIPK1TNK2 | |
| SCHEMBL22355507 | 0.86 | DOT1L (0.32) | DOT1LPOLRMTRIPK1TNK2 | |
| SCHEMBL19504133 | 0.86 | DOT1L (0.32) | DOT1LPOLRMTRIPK1TNK2 | |
| SCHEMBL18666884 | 0.86 | DOT1L (0.32) | DOT1LPOLRMTRIPK1TNK2 | |
| SCHEMBL22393430 | 0.85 | CYP3A4 (0.44) | DOT1LRIPK1 | |
| SCHEMBL22393558 | 0.85 | CYP3A4 (0.44) | DOT1LRIPK1 | |
| SCHEMBL22355553 | 0.84 | CYP3A4 (0.36) | DOT1LPOLRMTRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3785717-B1 | METHODS FOR TREATING CORONAVIRIDAE INFECTIONS | GILEAD SCIENCES INC (US) | 2022-01-05 | — | — | EP | disclosed |