Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 9/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.60 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.60 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.60 |
| ▸ | FECH | P22830 | 1/20 | 0.57 |
| ▸ | CDK8 | P49336 | 1/20 | 0.57 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.57 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24168215 | 0.91 | ALDH1A1 (0.59) | ALDH1A1MAPTHTTL3MBTL1EGFR | |
| SCHEMBL24168065 | 0.89 | MAPT (0.69) | ALDH1A1MAPTHTTL3MBTL1EGFR | |
| SCHEMBL24167709 | 0.89 | ALDH1A1 (0.57) | ALDH1A1MAPTHTTL3MBTL1EGFR | |
| SCHEMBL24167909 | 0.89 | ALDH1A1 (0.62) | ALDH1A1MAPTHTTL3MBTL1EGFR | |
| SCHEMBL24168200 | 0.89 | ALDH1A1 (0.56) | ALDH1A1MAPTHTTL3MBTL1EGFR | |
| SCHEMBL24167929 | 0.88 | ALDH1A1 (0.55) | ALDH1A1MAPTHTTL3MBTL1EGFR | |
| SCHEMBL24167628 | 0.87 | MAPT (0.56) | ALDH1A1MAPTHTTL3MBTL1EGFR | |
| SCHEMBL26006754 | 0.86 | ALDH1A1 (0.55) | ALDH1A1MAPTHTTL3MBTL1EGFR | |
| SCHEMBL26006752 | 0.86 | ALDH1A1 (0.55) | ALDH1A1MAPTHTTL3MBTL1EGFR | |
| SCHEMBL26006522 | 0.86 | ALDH1A1 (0.55) | ALDH1A1MAPTHTTL3MBTL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265098-A1 | ALKYNE QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN INC. | 2023-08-24 | — | — | US | disclosed |
| US-20230265098-A1 | ALKYNE QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN INC. | 2023-08-24 | — | — | US | disclosed |
| WO-2022006386-A1 | ALKYNE QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265098-A1 | ALKYNE QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 | ERBB2, ERBB3, CHEK2 | ALDH1A1 2707/4885MAPT 3141/4885HTT 3486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.