Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 5/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11410315 | 0.98 | P4HTM (0.50) | P4HTMPARP10ALDH1A1TDP1CYP3A4 | |
| SCHEMBL5755276 | 0.86 | P4HTM (0.63) | P4HTMPARP10ALDH1A1P4HA1MIF | |
| SCHEMBL3589291 | 0.83 | MAOB (0.53) | P4HTMALDH1A1P4HA1MIFKMT2A | |
| SCHEMBL11420514 | 0.83 | P4HTM (0.51) | P4HTMALDH1A1TDP1CYP3A4TSHR | |
| SCHEMBL753336 | 0.83 | P4HTM (0.53) | P4HTMALDH1A1P4HA1MIFKDM4E | |
| SCHEMBL10933975 | 0.83 | CDH1 (0.54) | P4HTMALDH1A1TDP1P4HA1MIF | |
| SCHEMBL11411697 | 0.83 | P4HTM (0.58) | P4HTMPARP10ALDH1A1P4HA1MIF | |
| SCHEMBL11410519 | 0.83 | KDM4E (0.65) | P4HTMALDH1A1P4HA1MIFKDM4E | |
| SCHEMBL10163267 | 0.82 | MAPK1 (0.54) | PARP10ALDH1A1TDP1CYP3A4TSHR | |
| SCHEMBL26116667 | 0.81 | KDM4E (0.46) | P4HTMPARP10ALDH1A1TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365752-A1 | CYCLOPROPANE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | Deciphera Pharmaceuticals, Llc (US) | 2011-09-21 | — | — | EP | disclosed |
| WO-2010051373-A1 | CYCLOPROPANE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2010-05-06 | — | — | WO | disclosed |