CDH1

Cadherin-1 · P12830 · CDH1 on Sugi Atlas →

1,939 patent compounds predicted against CDH1, 1,247 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL3469324 SCHEMBL3469324 1.00 2/20
SCHEMBL6740513 SCHEMBL6740513 0.40 2/20
SCHEMBL2260791 SCHEMBL2260791 1.00 1/20
SCHEMBL892967 SCHEMBL892967 0.82 1/20
SCHEMBL9953732 SCHEMBL9953732 0.81 1/20
SCHEMBL1258992 SCHEMBL1258992 0.74 1/20
SCHEMBL6291531 SCHEMBL6291531 0.73 1/20
SCHEMBL7262881 SCHEMBL7262881 0.72 1/20
Cercosporin Cercosporin (SCHEMBL498747) 0.71 1/20
Cercosporin Cercosporin (SCHEMBL6305985) 0.71 1/20
SCHEMBL1458816 SCHEMBL1458816 0.68 1/20
SCHEMBL892240 SCHEMBL892240 0.67 1/20
SCHEMBL6227154 SCHEMBL6227154 0.67 1/20
SCHEMBL11621542 SCHEMBL11621542 0.67 1/20
SCHEMBL11623030 SCHEMBL11623030 0.67 1/20
SCHEMBL6275897 SCHEMBL6275897 0.65 1/20
SCHEMBL7269138 SCHEMBL7269138 0.65 1/20
SCHEMBL10643646 SCHEMBL10643646 0.65 1/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL8591571) 0.63 1/20
SCHEMBL5696651 SCHEMBL5696651 0.62 1/20

Clinical trials — most relevant to CDH1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Identifying Predictors Of Response To Mepolizumab In CRSwNP PHASE4RECRUITING
Neoadjuvant Study of Targeting ROS1 in Combination With Endocrine Therapy in Invasive Lobular Carcinoma of the Breast (ROSALINE) PHASE2UNKNOWN
Avutometinib and Defactinib in Diffuse Gastric Cancer PHASE2RECRUITING
Erlotinib and Radiation Therapy in Treating Older Patients With Stage I, Stage II, Stage III, or Stage IV Esophageal Cancer PHASE2COMPLETED
Vinorelbine, Cisplatin, Disulfiram and Copper in CTC_EMT Positive Refractory Metastatic Breast Cancer. PHASE2WITHDRAWN
Can E-cadherin Found in Tissue/Blood be Valuable in Identifying & Monitoring Patients With Post-proton Pump Inhibitor (PPI)-Responsive Heartburn PHASE1COMPLETED
Phase Ib Study of Erlotinib Prior to Surgery in Patients With Head and Neck Cancer PHASE1COMPLETED
Interventional Therapy Sequential With the Fourth-generation CAR-T Targeting Nectin4/FAP for Malignant Solid Tumors PHASE1UNKNOWN
KRAS Wild-type Metastatic Colorectal Cancer Trial PHASE1COMPLETED
Predictive Value of E-cadherin, β-catenin and SOX4 in Recurrence and/or Progression of Non-muscle Invasive Urinary Bladder Transitional Cell Carcinoma. A Retrospective Study nanCOMPLETED
Expression of Epithelial-Mesenchymal Transition Associated Markers in Peri-implant Tissues nanRECRUITING
Epithelial Mesenchymal Transition Markers in OSMF nanCOMPLETED
CircularRNA-microRNA-mRNA Regulatory Axis in IVF nanNOT_YET_RECRUITING
Study on the Interplay Between Twist1 and Other EMT Regulators Through microRNA-29 Family. nanUNKNOWN
Profiling Gingival Crevicular Fluid β-Catenin Level With 8-OHdG and Total Antioxidants Capacity During Healing of Periodontal Pockets: A 3-month Clinical Trial nanNOT_YET_RECRUITING
Cell Membrane Potential Regulates Spatial-Specific Mechanoptosis Resistance and Metastasis in Colorectal Cancer Via Mechanotransduction and the PVR/CD96 Axis nanCOMPLETED
CDH1 Germline Mutations in Lobular Breast Cancer nanCOMPLETED
Influence of EMT on CTCs and Disease Progression in Prostate Cancer nanCOMPLETED
CDH1-associated Blepharocheilodontic Syndrome Registry nanRECRUITING
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression nanCOMPLETED
Impact of Molecular Pathological And Clinical Features for Adjuvant Treatment Selection in Endometrial Cancer: Asian Registry nanACTIVE_NOT_RECRUITING
Epithelial Mesenchymal Transition and Periodontitis nanUNKNOWN
Early Onset and Familial Gastric Cancer Registry nanCOMPLETED
Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer nanCOMPLETED
Studying the Role of Circulating Tumor Cell Clusters in Patients With High-risk Early Breast Cancer, Study GALIA nanRECRUITING
Role of Nox2 in CNI-induced Renal Fibrosis nanCOMPLETED
Association of Colorectal Cancer With Nutrition, Diet, Obesity, Diabetes Mellitus, and Genetic Alterations in Taiwan nanUNKNOWN
Detection of High Expression Levels of EMT-Transcription Factor mRNAs in Patients With Pancreatic Cancer and Their Diagnostic Potential nanUNKNOWN
Circulating Tumor Cell Detection in Patients With Luminal A Breast Cancer nanRECRUITING
Liquid Biopsies for the Personalized Management of Patients with Hereditary Diffuse Gastric Cancer nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a CDH1 binder may also engage these)

ProteinNameSimilarity
Q5RAX1 1.000 Q5RAX1 →
Q6R8F2 1.000 Q6R8F2 →
F1PAA9 1.000 F1PAA9 →
Q9R0T4 0.998 Q9R0T4 →
P08641 0.993 P08641 →
B2KI42 0.993 B2KI42 →
P20310 0.992 P20310 →
P19022 0.992 P19022 →
B4USZ0 0.992 B4USZ0 →
P09803 0.991 P09803 →
P15116 0.990 P15116 →
P19534 0.990 P19534 →
P79883 0.989 P79883 →
P10288 0.989 P10288 →
B0KW95 0.988 B0KW95 →
Q9Z1Y3 0.987 Q9Z1Y3 →
P10287 0.986 P10287 →
Q90275 0.986 Q90275 →
P33147 0.986 P33147 →
Q5R9X1 0.985 Q5R9X1 →
P22223 0.985 P22223 →
P19535 0.981 P19535 →
P33152 0.979 P33152 →
Q90Z37 0.973 Q90Z37 →
P33148 0.973 P33148 →
P39038 0.970 P39038 →
Q6URK6 0.965 Q6URK6 →
O02840 0.965 O02840 →
P33151 0.964 P33151 →
P55283 0.963 P55283 →