Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.60 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 4/20 | 0.53 |
| ▸ | JAK1 | P23458 | 3/20 | 0.53 |
| ▸ | TYK2 | P29597 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.48 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30368144 | 0.83 | TYK2 (0.56) | SMN1; SMN2ANO1RAB9ANPC1TYK2 | |
| SCHEMBL30367890 | 0.81 | SMN1; SMN2 (0.57) | SMN1; SMN2ANO1DNMT3BRAB9ANPC1 | |
| SCHEMBL30402922 | 0.81 | ANO1 (0.61) | SMN1; SMN2ANO1RAB9ANPC1ALDH1A1 | |
| SCHEMBL5639552 | 0.81 | SMN1; SMN2 (0.81) | SMN1; SMN2DNMT3BRAB9ANPC1JAK2 | |
| SCHEMBL24173209 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2DNMT3BRAB9ANPC1JAK2 | |
| SCHEMBL30502369 | 0.80 | KCNJ5 (0.68) | SMN1; SMN2ANO1RAB9ANPC1JAK2 | |
| SCHEMBL30368210 | 0.80 | ANO1 (0.65) | SMN1; SMN2ANO1JAK2JAK1TYK2 | |
| SCHEMBL30285596 | 0.78 | ALDH1A1 (0.53) | SMN1; SMN2ANO1RAB9ANPC1ALDH1A1 | |
| SCHEMBL26186439 | 0.78 | ALDH1A1 (0.53) | SMN1; SMN2ANO1RAB9ANPC1ALDH1A1 | |
| SCHEMBL30285772 | 0.78 | ANO1 (0.60) | SMN1; SMN2ANO1RAB9ANPC1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4171744-A1 | USE OF N-PHENYLACETAMIDES HAVING P2X4 RECEPTOR ANTAGONISTIC ACTIVITY FOR TREATING CERTAIN OCULAR DISORDERS | Bayer Aktiengesellschaft (DE) | 2023-05-03 | — | — | EP | claimed |
| EP-4172146-A1 | SUBSTITUTED N-PHENYLACETAMIDES HAVING P2X4 RECEPTOR ANTAGONISTIC ACTIVITY | Bayer Aktiengesellschaft (DE) | 2023-05-03 | — | — | EP | claimed |
| WO-2022002860-A1 | USE OF N-PHENYLACETAMIDES HAVING P2X4 RECEPTOR ANTAGONISTIC ACTIVITY FOR TREATING CERTAIN OCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 2022-01-06 | — | — | WO | disclosed |
| WO-2022002859-A1 | SUBSTITUTED N-PHENYLACETAMIDES HAVING P2X4 RECEPTOR ANTAGONISTIC ACTIVITY | BAYER AKTIENGESELLSCHAFT (DE) | 2022-01-06 | — | — | WO | disclosed |