Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 5/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.49 |
| ▸ | SCN1A | P35498 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2415714 | 0.87 | SCN10A (0.53) | SCN10AMAPTALDH1A1TDP1TSHR | |
| SCHEMBL14237415 | 0.85 | SCN10A (0.71) | SCN10ASCN9ASCN1ASCN5AMAPT | |
| SCHEMBL2418806 | 0.84 | SCN10A (0.53) | SCN10ASCN9ASCN1ASCN5AALDH1A1 | |
| SCHEMBL2416261 | 0.84 | SCN10A (0.75) | SCN10ASCN9ASCN1ASCN5AMAPT | |
| SCHEMBL2410050 | 0.84 | SCN10A (0.52) | SCN10ASCN9ASCN1ASCN5AMAPT | |
| SCHEMBL2415948 | 0.83 | SCN10A (0.54) | SCN10ASCN9ASCN1ASCN5AMAPT | |
| SCHEMBL2410195 | 0.83 | SCN10A (0.48) | SCN10AALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL2419090 | 0.82 | SCN10A (0.51) | SCN10ASCN9ASCN1ASCN5AMAPT | |
| SCHEMBL2420059 | 0.81 | SCN10A (0.54) | SCN10ASCN9ASCN1ASCN5AMAPT | |
| SCHEMBL2410516 | 0.81 | SCN10A (0.75) | SCN10ASCN9ASCN1ASCN5AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945630-B1 | PYRAZINE DERIVATIVES AS SODIUM CHANNEL MODULATORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2011-09-21 | — | — | EP | disclosed |