Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2414736 | 0.90 | SCN10A (0.48) | SCN10ALMNATSHRNPSR1SCN1A | |
| SCHEMBL2415948 | 0.84 | SCN10A (0.54) | SCN10ANPC1RAB9ALMNATSHR | |
| SCHEMBL2420059 | 0.84 | SCN10A (0.54) | SCN10ANPC1RAB9ALMNATSHR | |
| SCHEMBL2418091 | 0.84 | SCN10A (0.53) | SCN10ANPC1RAB9ALMNATSHR | |
| SCHEMBL2416261 | 0.84 | SCN10A (0.75) | SCN10ANPC1RAB9ALMNATSHR | |
| SCHEMBL2419090 | 0.81 | SCN10A (0.51) | SCN10ANPC1RAB9ALMNATSHR | |
| SCHEMBL2410050 | 0.80 | SCN10A (0.52) | SCN10ANPC1RAB9ASCN1ASCN5A | |
| SCHEMBL2415208 | 0.79 | SCN10A (0.50) | SCN10ANPC1RAB9ALMNASCN1A | |
| SCHEMBL2410516 | 0.79 | SCN10A (0.75) | SCN10ANPC1RAB9ALMNASCN1A | |
| SCHEMBL2416063 | 0.77 | SCN10A (0.48) | SCN10ANPC1RAB9ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945630-B1 | PYRAZINE DERIVATIVES AS SODIUM CHANNEL MODULATORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2011-09-21 | — | — | EP | disclosed |