Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24181543 | 0.88 | PTPN11 (0.48) | PTPN11 | |
| SCHEMBL25967219 | 0.87 | PTPN11 (0.68) | PTPN11KCNH2 | |
| SCHEMBL24181555 | 0.87 | PTPN11 (0.47) | PTPN11 | |
| SCHEMBL24181551 | 0.85 | PTPN11 (0.50) | PTPN11 | |
| SCHEMBL24181700 | 0.85 | PTPN11 (0.57) | PTPN11KCNH2 | |
| SCHEMBL24378951 | 0.82 | PTPN11 (0.64) | PTPN11 | |
| SCHEMBL27263374 | 0.82 | PTPN11 (0.42) | PTPN11 | |
| SCHEMBL24181683 | 0.82 | PTPN11 (0.49) | PTPN11 | |
| SCHEMBL24181562 | 0.82 | PTPN11 (0.50) | PTPN11 | |
| SCHEMBL24181584 | 0.82 | PTPN11 (0.47) | PTPN11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3936502-A1 | PYRAZINE DERIVATIVE AND APPLICATION THEREOF IN INHIBITING SHP2 | Suzhou Genhouse Pharmaceutical Co., Ltd. (CN) | 2022-01-12 | — | — | EP | disclosed |