Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24181566 | 0.87 | PTPN11 (0.51) | PTPN11KCNH2 | |
| SCHEMBL20388797 | 0.87 | PTPN11 (0.62) | PTPN11KCNH2 | |
| SCHEMBL24181551 | 0.86 | PTPN11 (0.50) | PTPN11 | |
| SCHEMBL24861032 | 0.85 | PTPN11 (0.72) | PTPN11KCNH2 | |
| SCHEMBL24181543 | 0.84 | PTPN11 (0.48) | PTPN11 | |
| SCHEMBL24181562 | 0.84 | PTPN11 (0.50) | PTPN11 | |
| SCHEMBL24181680 | 0.84 | PTPN11 (0.47) | PTPN11 | |
| SCHEMBL24181584 | 0.84 | PTPN11 (0.47) | PTPN11KCNH2 | |
| SCHEMBL24181521 | 0.84 | PTPN11 (0.47) | PTPN11 | |
| SCHEMBL24181683 | 0.84 | PTPN11 (0.49) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122938-A1 | HETEROCYCLIC COMPOUNDS AS SHP2 INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF | JS INNOMED HOLDINGS LTD. (KY) | 2023-07-06 | — | — | WO | disclosed |