Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 15/20 | 0.48 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2427785 | 0.88 | EGLN1 (0.51) | EGLN1SSTR5KCNH2PTGDRCHRM2 | |
| SCHEMBL2418614 | 0.87 | EGLN1 (0.52) | EGLN1SSTR5CHRM2CHRM3 | |
| SCHEMBL2419968 | 0.87 | EGLN1 (0.50) | EGLN1SSTR5KCNH2PTGDR | |
| SCHEMBL2426861 | 0.83 | EGLN1 (0.50) | EGLN1SSTR5KCNH2CHRM2CHRM3 | |
| SCHEMBL2419405 | 0.82 | SSTR5 (0.61) | SSTR5KCNH2PTGDR | |
| SCHEMBL5420730 | 0.76 | EGLN1 (0.58) | EGLN1 | |
| SCHEMBL2425791 | 0.76 | SSTR5 (0.43) | SSTR5KCNH2CHRM2CHRM3 | |
| SCHEMBL2422272 | 0.74 | SSTR5 (0.64) | SSTR5KCNH2CHRM2CHRM3 | |
| SCHEMBL3871205 | 0.70 | SSTR5 (0.47) | SSTR5KCNH2 | |
| SCHEMBL10111365 | 0.70 | SSTR5 (0.61) | SSTR5KCNH2PTGDRCHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152710-A2 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-02-17 | — | — | EP | claimed |
| WO-2008145524-A2 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-12-04 | — | — | WO | claimed |
| US-20080293756-A1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-27 | — | — | US | claimed |
| US-8026365-B2 | 4,4-disubstituted piperidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-09-27 | — | — | US | disclosed |
| EP-2152710-A2 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008145524-A2 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-12-04 | — | — | WO | disclosed |
| US-20080293756-A1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293756-A1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | SSTR5, SSTR4, SSTR1 | EGLN1 1350/4885SSTR5 1/4885KCNH2 811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.