Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 20/20 | 0.65 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.65 |
| ▸ | MMP2 | P08253 | 4/20 | 0.60 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.59 |
| ▸ | MMP13 | P45452 | 1/20 | 0.59 |
| ▸ | MMP1 | P03956 | 1/20 | 0.59 |
| ▸ | MMP12 | P39900 | 1/20 | 0.59 |
| ▸ | MMP14 | P50281 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24187376 | 1.00 | ADAMTS5 (0.65) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL24187285 | 1.00 | ADAMTS5 (0.65) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL24187233 | 0.91 | ADAMTS5 (0.66) | ADAMTS5ADAM17MMP2ADAMTS4MMP14 | |
| SCHEMBL24187336 | 0.89 | ADAMTS5 (0.59) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL24187255 | 0.87 | ADAMTS5 (0.68) | ADAMTS5MMP2ADAMTS4MMP14 | |
| SCHEMBL24187277 | 0.87 | ADAMTS5 (0.68) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL24187270 | 0.85 | ADAMTS5 (0.63) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL24187310 | 0.85 | ADAMTS5 (0.61) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL24187244 | 0.85 | ADAMTS5 (0.63) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL24187374 | 0.85 | ADAMTS5 (0.63) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115720578-A | Tricyclic derivative, preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2023-02-28 | — | — | CN | disclosed |
| WO-2022007866-A1 | FUSED TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | 深圳信立泰药业股份有限公司 | 2022-01-13 | — | — | WO | disclosed |