Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31618908 | 1.00 | MAPT (0.45) | MAPTLMNAALDH1A1IDO1TDO2 | |
| SCHEMBL5913105 | 0.91 | SMN1; SMN2 (0.48) | MAPTLMNAALDH1A1IDO1TDO2 | |
| SCHEMBL31618922 | 0.91 | SMN1; SMN2 (0.48) | MAPTLMNAALDH1A1IDO1TDO2 | |
| SCHEMBL24187485 | 0.86 | GPR119 (0.46) | MAPTLMNAALDH1A1MAP4K4SMARCA2 | |
| SCHEMBL31618902 | 0.86 | GPR119 (0.46) | MAPTLMNAALDH1A1MAP4K4SMARCA2 | |
| SCHEMBL19582522 | 0.85 | MAPT (0.51) | MAPTLMNAALDH1A1MAP4K4SMARCA2 | |
| SCHEMBL29417615 | 0.85 | MAPT (0.51) | MAPTLMNAALDH1A1MAP4K4SMARCA2 | |
| SCHEMBL19260951 | 0.85 | MEN1 (0.52) | MAPTLMNAALDH1A1MAP4K4SMARCA2 | |
| SCHEMBL24187486 | 0.85 | BACE1 (0.51) | MAPTLMNAALDH1A1MAP4K4SMARCA2 | |
| SCHEMBL29417701 | 0.85 | MEN1 (0.52) | MAPTLMNAALDH1A1MAP4K4SMARCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115720578-A | Tricyclic derivative, preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2023-02-28 | — | — | CN | disclosed |
| WO-2022007866-A1 | FUSED TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | 深圳信立泰药业股份有限公司 | 2022-01-13 | — | — | WO | disclosed |