Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 19/20 | 0.70 |
| ▸ | MMP13 | P45452 | 2/20 | 0.70 |
| ▸ | MMP2 | P08253 | 3/20 | 0.69 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.66 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.64 |
| ▸ | MMP1 | P03956 | 1/20 | 0.64 |
| ▸ | MMP12 | P39900 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24187377 | 0.85 | ADAMTS5 (0.70) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL17871398 | 0.82 | ADAMTS5 (1.00) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL21582730 | 0.82 | ADAMTS5 (1.00) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL21582729 | 0.82 | ADAMTS5 (1.00) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL17871340 | 0.82 | ADAMTS5 (1.00) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL17871366 | 0.82 | ADAMTS5 (1.00) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL20708258 | 0.81 | ADAMTS5 (0.82) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL20708329 | 0.80 | ADAMTS5 (0.84) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL20708606 | 0.80 | ADAMTS5 (0.84) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL17871287 | 0.80 | ADAMTS5 (1.00) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022007866-A1 | FUSED TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | 深圳信立泰药业股份有限公司 | 2022-01-13 | — | — | WO | disclosed |