Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 12/20 | 0.53 |
| ▸ | ATP4B | P51164 | 12/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5623480 | 0.99 | ATP4A (0.53) | ATP4AATP4BKMT2AMEN1NPC1 | |
| SCHEMBL2380491 | 0.92 | ATP4A (0.53) | ATP4AATP4B | |
| SCHEMBL2380405 | 0.91 | ATP4A (0.49) | ATP4AATP4BKMT2AMEN1ALDH1A1 | |
| SCHEMBL2449269 | 0.89 | ATP4A (0.67) | ATP4AATP4BNPC1ALDH1A1 | |
| SCHEMBL2446392 | 0.88 | ATP4A (0.51) | ATP4AATP4BKMT2AMEN1NPC1 | |
| Bromide SCHEMBL2379078 | 0.88 | ATP4A (0.68) | ATP4AATP4BNPC1ALDH1A1 | |
| Bromide SCHEMBL2378136 | 0.87 | ATP4A (0.50) | ATP4AATP4BKMT2AMEN1NPC1 | |
| SCHEMBL2451046 | 0.87 | ATP4A (0.56) | ATP4AATP4BKMT2AMEN1NPC1 | |
| SCHEMBL2382010 | 0.87 | ATP4A (0.55) | ATP4AATP4BNPC1CYP1A1CYP1B1 | |
| Bromide SCHEMBL2379940 | 0.86 | ATP4A (0.57) | ATP4AATP4BKMT2AMEN1CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716127-B1 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2014-08-06 | — | — | EP | disclosed |
| EP-2380885-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366392-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |
| EP-2366697-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |