SCHEMBL2419065

SCHEMBL2419065

O=C1C=CC2=CCC(=O)N=C2C1

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GSK3A P49840 1/20 0.39
GSK3B P49841 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16934682 0.67
SCHEMBL337485 0.65 GSK3A (0.42) GSK3AGSK3B
SCHEMBL277815 0.60
SCHEMBL366153 0.56 GSK3A (0.71) GSK3AGSK3B
SCHEMBL3886056 0.55 GSK3A (0.32) GSK3AGSK3B
SCHEMBL6156232 0.55 GSK3A (0.32) GSK3AGSK3B
SCHEMBL4065553 0.54 CFTR (0.37) GSK3AGSK3B
SCHEMBL10597586 0.52
SCHEMBL7711268 0.51 GSK3A (0.43) GSK3AGSK3B
SCHEMBL19472021 0.51

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001016139-A9 ANDROGEN RECEPTOR MODULATOR COMPOUNDS AND METHODS LIGAND PHARM INC (US) 2002-09-19 WO claimed
EP-2362872-A2 DECAHYDRO-1H-INDENOQUINOLINONE AND DECAHYDRO-3H-CYCLOPENTAPHENANTHRIDINONE CYP17 INHIBITORS BioMarin Pharmaceutical Inc. (US) 2011-09-07 EP disclosed
WO-2010062506-A2 DECAHYDRO-1H-INDENOQUINOLINONE AND DECAHYDRO-3H-CYCLOPENTAPHENANTHRIDINONE CYP17 INHIBITORS LEAD THERAPEUTICS, INC. (US) 2010-06-03 WO disclosed
EP-1021397-A4 BENZANTHRONE COMPOUNDS AND ANTIVIRAL USES THEREOF TRIMERIS INC (US) 2000-10-04 EP disclosed
EP-1021397-A1 BENZANTHRONE COMPOUNDS AND ANTIVIRAL USES THEREOF TRIMERIS INC. (US) 2000-07-26 EP disclosed
WO-1998039287-A1 BENZANTHRONE COMPOUNDS AND ANTIVIRAL USES THEREOF TRIMERIS, INC. (US) 1998-09-11 WO disclosed
EP-0288400-A1 Substituted isoquinolines EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1988-10-26 EP disclosed