Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | BIRC2 | Q13490 | 3/20 | 0.35 |
| ▸ | XIAP | P98170 | 2/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.31 |
| ▸ | AHR | P35869 | 2/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.30 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.30 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21964248 | 0.83 | AHR (0.35) | BIRC2XIAPCRBNPDE3BPDE3A | |
| SCHEMBL24191809 | 0.80 | GRIA1 (0.34) | BIRC2XIAPSMYD3PDE3BPDE3A | |
| SCHEMBL15806897 | 0.71 | CYP2C19 (0.42) | PDE3BPDE3AAHRPDK2 | |
| SCHEMBL24192469 | 0.71 | AHR (0.38) | PDE3BPDE3AAHRPDK2ALDH1A1 | |
| SCHEMBL8652640 | 0.70 | PDE3B (0.35) | POLBPDE3BPDE3AAHRPDK2 | |
| SCHEMBL24191804 | 0.70 | SMYD3 (0.43) | SMYD3CRBNPDE3BPDE3AAHR | |
| SCHEMBL18237934 | 0.69 | CRBN (0.42) | POLBCRBNPDE3BPDE3AALDH1A1 | |
| SCHEMBL25970121 | 0.69 | AHR (0.49) | SMYD3PDE3BPDE3AAHRPDK2 | |
| SCHEMBL24192092 | 0.69 | AHR (0.49) | SMYD3PDE3BPDE3AAHRPDK2 | |
| SCHEMBL7037819 | 0.69 | AHR (0.49) | SMYD3PDE3BPDE3AAHRPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230257396-A1 | MACROCYCLES AND THEIR USE | BLOSSOMHILL THERAPEUTICS INC (US) | 2023-08-17 | — | — | US | disclosed |
| US-20230257396-A1 | MACROCYCLES AND THEIR USE | BLOSSOMHILL THERAPEUTICS INC (US) | 2023-08-17 | — | — | US | disclosed |
| WO-2022011123-A1 | MACROCYCLES AND THEIR USE | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2022-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230257396-A1 | MACROCYCLES AND THEIR USE | VHL, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, DLD | POLB 931/4885BIRC2 365/4885XIAP 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.