Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | F2R | P25116 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2124479 | 0.83 | CYP19A1 (0.64) | CYP19A1MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL2124481 | 0.83 | CYP19A1 (0.64) | CYP19A1MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL2420496 | 0.82 | CYP19A1 (1.00) | CYP19A1MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL2123393 | 0.80 | CYP19A1 (0.57) | CYP19A1MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL2421702 | 0.78 | CYP19A1 (0.69) | CYP19A1MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL23320511 | 0.77 | CYP19A1 (0.63) | CYP19A1MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL21244768 | 0.77 | NR1I2 (0.48) | CYP19A1KMT2AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL23320526 | 0.77 | CYP19A1 (0.67) | CYP19A1MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL11703292 | 0.76 | KMT2A (0.59) | MEN1KMT2AL3MBTL1MAPTLMNA | |
| SCHEMBL22004367 | 0.76 | CYP11B1 (0.42) | CYP19A1MEN1KMT2APGRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049480-B1 | 2-ARYLINDOLE DERIVATIVES AS mPGES-1 INHIBITORS | ACRAF (IT) | 2013-10-30 | — | — | EP | disclosed |
| CN-101490000-B | 2-Arylindole derivatives as mPGEs-1 inhibitors | ACRAF | 2012-10-03 | — | — | CN | disclosed |
| US-8017644-B2 | 2-arylindole derivatives as nPGES-1 inhibitors | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2011-09-13 | — | — | US | disclosed |
| US-20090186922-A1 | 2-ARYLINDOLE DERIVATIVES AS NPGES-I INHIBITORS | AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A. (IT) | 2009-07-23 | — | — | US | disclosed |
| CN-101490000-A | 2-arylindole derivatives as NPGES-1 inhibitors | ACRAF (IT) | 2009-07-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186922-A1 | 2-ARYLINDOLE DERIVATIVES AS NPGES-I INHIBITORS | PTGES, NAT1, CSNK1G2 | CYP19A1 636/4885MEN1 4607/4885KMT2A 1109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.