Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 7/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24196453 | 0.88 | HSD17B10 (0.45) | ALDH1A1MAPK1MEN1KMT2AKDM4E | |
| SCHEMBL24196194 | 0.84 | KIT (0.47) | ALDH1A1MEN1KMT2AHSD17B10KIT | |
| SCHEMBL24195978 | 0.84 | CHEK1 (0.42) | ALDH1A1MAPK1MEN1KMT2AKDM4E | |
| SCHEMBL22001270 | 0.76 | MAP4K4 (0.50) | ALDH1A1KITAAK1PIK3CBDYRK1A | |
| SCHEMBL22347554 | 0.75 | CYP3A4 (0.50) | ALDH1A1MAPK1MEN1CYP11B1CYP11B2 | |
| SCHEMBL21044419 | 0.74 | PIM2 (0.51) | CYP11B1CYP11B2 | |
| SCHEMBL1336962 | 0.74 | MAP4K4 (0.53) | ALDH1A1MAPK1MEN1KMT2AKDM4E | |
| Benzene SCHEMBL27860902 | 0.74 | NPC1 (0.49) | ALDH1A1MAPK1MEN1KMT2AKDM4E | |
| SCHEMBL21044415 | 0.74 | CYP11B1 (0.66) | ALDH1A1MAPK1MEN1KMT2AKDM4E | |
| SCHEMBL24196485 | 0.73 | KDM4E (0.44) | ALDH1A1MAPK1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022011274-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2022-01-13 | — | — | WO | disclosed |
| WO-2022011274-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2022-01-13 | — | — | WO | disclosed |