Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24196283 | 0.88 | ALDH1A1 (0.47) | HSD17B10NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL22347554 | 0.75 | CYP3A4 (0.50) | NPC1RAB9ATP53SMN1; SMN2ALDH1A1 | |
| Benzene SCHEMBL27860902 | 0.74 | NPC1 (0.49) | NPC1RAB9ATP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL171947 | 0.73 | TP53 (0.48) | HSD17B10NPC1RAB9ATP53PKM | |
| SCHEMBL24196194 | 0.72 | KIT (0.47) | HSD17B10NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17472599 | 0.72 | S1PR1 (0.43) | DYRK1AMAPK10S1PR1S1PR3 | |
| SCHEMBL8181149 | 0.72 | TDP1 (0.55) | HSD17B10NPC1RAB9ATP53PKM | |
| SCHEMBL24195978 | 0.72 | CHEK1 (0.42) | HSD17B10MAPTALDH1A1MAPK1KDM4E | |
| SCHEMBL2684785 | 0.71 | AAK1 (0.53) | HSD17B10SMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL31472553 | 0.71 | PI4KA (0.73) | HSD17B10TP53ALDH1A1PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022011274-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2022-01-13 | — | — | WO | disclosed |
| WO-2022011274-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2022-01-13 | — | — | WO | disclosed |