Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 4/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.36 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16992932 | 0.85 | CYP17A1 (0.44) | CYP17A1SYKRORCAAK1RXFP1 | |
| SCHEMBL3344049 | 0.84 | AAK1 (0.45) | CYP17A1SYKRORCAAK1RXFP1 | |
| SCHEMBL14923617 | 0.84 | CYP17A1 (0.43) | CYP17A1SYKRORCAAK1RXFP1 | |
| SCHEMBL23483654 | 0.83 | CYP17A1 (0.42) | CYP17A1SYKRORCAAK1RXFP1 | |
| SCHEMBL29918800 | 0.83 | CYP17A1 (0.42) | CYP17A1SYKRORCAAK1RXFP1 | |
| SCHEMBL24195797 | 0.82 | ASPH (0.46) | CYP17A1SYKRORCAAK1RXFP1 | |
| SCHEMBL24195944 | 0.81 | CYP17A1 (0.41) | CYP17A1SYKRORCAAK1RXFP1 | |
| SCHEMBL24196208 | 0.81 | CYP17A1 (0.41) | CYP17A1SYKRORCAAK1RXFP1 | |
| SCHEMBL24195947 | 0.81 | AAK1 (0.41) | CYP17A1SYKRORCAAK1RXFP1 | |
| SCHEMBL24195800 | 0.81 | ATR (0.42) | CYP17A1SYKRORCRXFP1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022011274-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2022-01-13 | — | — | WO | disclosed |
| WO-2022011274-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2022-01-13 | — | — | WO | disclosed |