Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.31 |
| ▸ | TNKS | O95271 | 1/20 | 0.31 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.31 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24156575 | 0.84 | KDM4E (0.46) | KDM4ETYMSPARP1PARP2ALDH1A1 | |
| SCHEMBL30212555 | 0.84 | KDM4E (0.46) | KDM4ETYMSPARP1PARP2ALDH1A1 | |
| SCHEMBL30212546 | 0.84 | KDM4E (0.46) | KDM4ETYMSHCAR2PARP1PARP2 | |
| SCHEMBL24157228 | 0.84 | KDM4E (0.46) | KDM4ETYMSHCAR2PARP1PARP2 | |
| SCHEMBL24157226 | 0.78 | KDM4E (0.48) | KDM4EPARP1PARP2ALDH1A1HSD17B10 | |
| SCHEMBL30297076 | 0.78 | KDM4E (0.48) | KDM4EPARP1PARP2ALDH1A1HSD17B10 | |
| SCHEMBL24157278 | 0.78 | KDM4E (0.48) | KDM4ETYMSPARP1PARP2ALDH1A1 | |
| SCHEMBL30297085 | 0.78 | KDM4E (0.48) | KDM4ETYMSPARP1PARP2ALDH1A1 | |
| SCHEMBL30212587 | 0.76 | PARP1 (0.46) | KDM4EPARP1PARP2LMNATNKS | |
| SCHEMBL31097523 | 0.75 | KDM4E (0.44) | KDM4EPARP1PARP2ALDH1A1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11795158-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2023-10-24 | — | — | US | disclosed |
| US-20220009901-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2022-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11795158-B2 | Chemical compounds | CYP11B2, CYP11B1, CYP4B1 | KDM4E 544/4885TYMS 466/4885HCAR2 1815/4885 |
| US-20220009901-A1 | CHEMICAL COMPOUNDS | CYP11B2, CYP11B1, CYP4B1 | KDM4E 544/4885TYMS 466/4885HCAR2 1815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.