Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 3/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13230548 | 0.84 | BACE1 (0.49) | TAS1R3TAS1R1BACE1MEN1POLB | |
| SCHEMBL3791740 | 0.82 | BACE1 (0.53) | TAS1R3TAS1R1BACE1MEN1POLB | |
| SCHEMBL3794968 | 0.79 | BACE1 (0.50) | TAS1R3TAS1R1BACE1MEN1POLB | |
| Dimethylamine SCHEMBL6744099 | 0.78 | BACE1 (0.49) | TAS1R3TAS1R1BACE1MEN1POLB | |
| SCHEMBL28523093 | 0.76 | BACE1 (0.48) | BACE1MEN1POLBMAPK1KMT2A | |
| SCHEMBL31271 | 0.75 | AHR (0.50) | BACE1MEN1POLBMAPK1KMT2A | |
| SCHEMBL6743711 | 0.74 | DRD2 (0.51) | BACE1KDM4EHSD17B10 | |
| SCHEMBL15980816 | 0.74 | BACE1 (0.46) | TAS1R3TAS1R1BACE1MEN1POLB | |
| SCHEMBL13230520 | 0.74 | ACACB (0.46) | TAS1R3TAS1R1BACE1MEN1POLB | |
| SCHEMBL28853730 | 0.72 | MEN1 (0.53) | TAS1R3TAS1R1BACE1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939986-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | Prelude Therapeutics, Incorporated (US) | 2022-01-19 | — | — | EP | disclosed |