Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | CPN1 | P15169 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12324060 | 0.83 | GPR119 (0.44) | KMT2AMEN1PKMALDH1A1 | |
| SCHEMBL5508506 | 0.82 | CHRM3 (0.46) | KMT2AMEN1CHRM3 | |
| SCHEMBL5508508 | 0.82 | CHRM3 (0.46) | KMT2AMEN1CHRM3 | |
| SCHEMBL27689759 | 0.82 | CHRM3 (0.46) | KMT2AMEN1CHRM3 | |
| SCHEMBL2419978 | 0.81 | KMT2A (0.34) | KMT2AMEN1PKMCHRM3C3AR1 | |
| SCHEMBL28510054 | 0.78 | CYP2D6 (0.45) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL28779403 | 0.78 | DHODH (0.42) | CHRM3ALDH1A1POLB | |
| SCHEMBL18034384 | 0.76 | IDO1 (0.42) | C3AR1 | |
| SCHEMBL15550386 | 0.75 | IDO1 (0.44) | C3AR1 | |
| SCHEMBL4975353 | 0.74 | DPP4 (0.42) | KMT2AALDH1A1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547664-B1 | MORPHOLINYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2016-05-04 | — | — | EP | disclosed |
| EP-2547664-A1 | MORPHOLINYLQUINAZOLINES | Merck Patent GmbH (DE) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011113512-A1 | MORPHOLINYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2011-09-22 | — | — | WO | disclosed |