Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.55 |
| ▸ | HPGD | P15428 | 10/20 | 0.55 |
| ▸ | GLA | P06280 | 7/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.55 |
| ▸ | GAA | P10253 | 6/20 | 0.55 |
| ▸ | HTT | P42858 | 5/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24200430 | 0.74 | KDM4E (0.70) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL20158977 | 0.73 | KDM4E (0.68) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL21341228 | 0.71 | KDM4E (0.45) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL24200393 | 0.70 | RET (0.40) | ALDH1A1HPGDHTTMAPK1LMNA | |
| SCHEMBL31232939 | 0.69 | BCHE (0.54) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL24200425 | 0.69 | ALKBH5 (0.41) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL20159028 | 0.68 | KDM4E (0.54) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL3677398 | 0.66 | ERN1 (0.56) | KDM4EALDH1A1MAPK1LMNAMAPT | |
| SCHEMBL14956243 | 0.66 | BCHE (0.59) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL343958 | 0.66 | TRIM24 (0.65) | ALDH1A1HPGDGAAHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538529-B1 | SELECTIVE INHIBITORS OF GENOTOXIC STRESS-INDUCED IKK/NF-KB PATHWAYS | MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN HELMHOLTZ GEMEINSCHAFT (DE) | 2022-01-19 | — | — | EP | disclosed |