Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20404493 | 0.92 | — | — | |
| SCHEMBL18610399 | 0.90 | CHRM2 (0.30) | CHRM2CHRM1CHRM3 | |
| SCHEMBL27373440 | 0.84 | — | — | |
| SCHEMBL19557854 | 0.83 | — | — | |
| SCHEMBL19017571 | 0.83 | — | — | |
| SCHEMBL17896486 | 0.80 | GLA (0.32) | CHRM2CHRM1CHRM3 | |
| SCHEMBL18812363 | 0.79 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL22891808 | 0.78 | CCR2 (0.36) | — | |
| SCHEMBL24335699 | 0.78 | — | — | |
| SCHEMBL21441583 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939964-A1 | COMBINATIONS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS | Ardelyx, Inc. (US) | 2022-01-19 | — | — | EP | disclosed |