Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28342738 | 0.85 | NPSR1 (0.53) | MAPTMAPK1NPSR1L3MBTL1EPHX2 | |
| SCHEMBL2216450 | 0.84 | CYP2D6 (0.51) | NPSR1L3MBTL1TSHRCYP2C9CYP2C19 | |
| SCHEMBL16415925 | 0.82 | HIF1A (0.39) | MAPK1NPSR1TSHRCYP2C9CYP2C19 | |
| SCHEMBL28825961 | 0.78 | TSHR (0.43) | MAPTMAPK1NPSR1L3MBTL1EPHX2 | |
| SCHEMBL28340273 | 0.77 | NPSR1 (0.50) | MAPTMAPK1NPSR1L3MBTL1EPHX2 | |
| SCHEMBL435610 | 0.76 | CYP2C9 (0.45) | MAPK1EPHX2TSHRCYP2C9CYP2C19 | |
| SCHEMBL15015792 | 0.76 | TSHR (0.41) | MAPTMAPK1NPSR1L3MBTL1EPHX2 | |
| SCHEMBL2422763 | 0.75 | MAPT (0.40) | MAPTMAPK1NPSR1L3MBTL1EPHX2 | |
| SCHEMBL1032475 | 0.74 | LCK (0.47) | MAPTEPHX2TSHRCYP2C9CYP2C19 | |
| SCHEMBL13518496 | 0.74 | TSHR (0.44) | MAPTMAPK1NPSR1L3MBTL1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364297-A1 | Compounds, pharmaceutical composition and methods for use in treating metabolic disorders | Euroscreen S.A. (BE) | 2011-09-14 | — | — | EP | disclosed |