Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.79 |
| ▸ | MAPT | P10636 | 8/20 | 0.79 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PRKDC | P78527 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | TNNI3 | P19429 | 2/20 | 0.48 |
| ▸ | TNNT2 | P45379 | 2/20 | 0.48 |
| ▸ | TNNC1 | P63316 | 2/20 | 0.48 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2426964 | 0.83 | ALDH1A1 (0.56) | ALDH1A1MAPTALDH1A3KDM4ETDP1 | |
| SCHEMBL2419486 | 0.83 | ALDH1A1 (0.56) | ALDH1A1MAPTALDH1A3KDM4ETDP1 | |
| SCHEMBL5560563 | 0.81 | ALDH1A1 (0.88) | ALDH1A1MAPTALDH1A3KDM4ETDP1 | |
| SCHEMBL8381926 | 0.81 | ALDH1A1 (0.87) | ALDH1A1MAPTALDH1A3KDM4ETDP1 | |
| SCHEMBL2424543 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPTALDH1A3KDM4ETDP1 | |
| SCHEMBL2427187 | 0.79 | ALDH1A1 (0.52) | ALDH1A1MAPTALDH1A3KDM4ETDP1 | |
| SCHEMBL5059626 | 0.78 | ALDH1A1 (0.61) | ALDH1A1MAPTALDH1A3KDM4ETDP1 | |
| SCHEMBL2462817 | 0.77 | ALDH1A1 (0.50) | ALDH1A1MAPTALDH1A3KDM4ETDP1 | |
| SCHEMBL17871817 | 0.77 | ALDH1A1 (0.56) | ALDH1A1MAPTALDH1A3KDM4ETDP1 | |
| SCHEMBL28034017 | 0.77 | ALDH1A1 (0.56) | ALDH1A1MAPTALDH1A3SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150051185-A1 | Chemical Compounds 251 | ASTRAZENECA AB (SE) | 2015-02-19 | — | — | US | disclosed |
| US-20150051185-A1 | Chemical Compounds 251 | ASTRAZENECA AB (SE) | 2015-02-19 | — | — | US | disclosed |
| US-20150051185-A1 | Chemical Compounds 251 | ASTRAZENECA AB (SE) | 2015-02-19 | — | — | US | disclosed |
| US-8901307-B2 | Chemical compounds 251 | ASTRAZENECA AB (SE) | 2014-12-02 | — | — | US | disclosed |
| US-8901307-B2 | Chemical compounds 251 | ASTRAZENECA AB (SE) | 2014-12-02 | — | — | US | disclosed |
| US-8901307-B2 | Chemical compounds 251 | ASTRAZENECA AB (SE) | 2014-12-02 | — | — | US | disclosed |
| US-20110218182-A1 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2011-09-08 | — | — | US | disclosed |
| US-20110218182-A1 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2011-09-08 | — | — | US | disclosed |
| US-20110218182-A1 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2011-09-08 | — | — | US | disclosed |
| WO-2010001169-A2 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218182-A1 | CHEMICAL COMPOUNDS 251 | PIM1, PIM3, PIM2 | ALDH1A1 498/4885MAPT 3102/4885ALDH1A3 1557/4885 |
| US-20150051185-A1 | Chemical Compounds 251 | PIM1, PIM3, PIM2 | ALDH1A1 683/4885MAPT 3277/4885ALDH1A3 1829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.