Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 4/20 | 0.40 |
| ▸ | ATP4B | P51164 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 4/20 | 0.37 |
| ▸ | JUND | P17535 | 1/20 | 0.36 |
| ▸ | FOSB | P53539 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2381600 | 0.99 | ATP4A (0.40) | ATP4AATP4BHTR2CJUNDFOSB | |
| SCHEMBL2380075 | 0.85 | ATP4A (0.40) | ATP4AATP4BADORA2AROCK2 | |
| Hydrochloric Acid SCHEMBL2378942 | 0.85 | ATP4A (0.39) | ATP4AATP4BADORA2AROCK2 | |
| SCHEMBL2379370 | 0.83 | TSHR (0.45) | ATP4AATP4BCDK1CDK4CCND1 | |
| SCHEMBL2380476 | 0.80 | ATP4A (0.51) | ATP4AATP4BNPC1MAPTRAB9A | |
| SCHEMBL2380081 | 0.80 | ATP4A (0.39) | ATP4AATP4BADORA2AROCK2 | |
| SCHEMBL2379444 | 0.80 | ATP4A (0.44) | ATP4AATP4BADORA2AALOX12NPC1 | |
| SCHEMBL2380595 | 0.79 | ATP4A (0.53) | ATP4AATP4BNPC1MAPTRAB9A | |
| SCHEMBL2449269 | 0.79 | ATP4A (0.67) | ATP4AATP4BNPC1MAPTRAB9A | |
| SCHEMBL2422694 | 0.78 | TMIGD3 (0.40) | HTR2CJUNDFOSBADORA2AF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716127-B1 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2014-08-06 | — | — | EP | disclosed |
| EP-2380885-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366392-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |
| EP-2366697-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |