Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.72 |
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | POLB | P06746 | 3/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.72 |
| ▸ | RXFP1 | Q9HBX9 | 7/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 9/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1915613 | 0.85 | TDP1 (0.66) | ALDH1A1SMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL1916359 | 0.83 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL4473418 | 0.76 | RXFP1 (0.70) | ALDH1A1SMN1; SMN2KMT2AMEN1RXFP1 | |
| SCHEMBL1914837 | 0.75 | TDP1 (0.64) | ALDH1A1SMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL1915349 | 0.73 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL2835357 | 0.73 | RXFP1 (0.70) | ALDH1A1SMN1; SMN2KMT2AMEN1RXFP1 | |
| SCHEMBL1914731 | 0.73 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL1917022 | 0.72 | MEN1 (0.74) | ALDH1A1SMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL1915242 | 0.72 | POLB (0.55) | ALDH1A1SMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL2398140 | 0.71 | ALDH1A1 (0.76) | ALDH1A1SMN1; SMN2KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364297-A1 | Compounds, pharmaceutical composition and methods for use in treating metabolic disorders | Euroscreen S.A. (BE) | 2011-09-14 | — | — | EP | claimed |
| WO-2010066682-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS | EUROSCREEN S.A. (BE) | 2010-06-17 | — | — | WO | claimed |