Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.65 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.65 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.65 |
| ▸ | CLK1 | P49759 | 3/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.65 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.65 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.65 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.65 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.65 |
| ▸ | CLK3 | P49761 | 1/20 | 0.65 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.65 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.65 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.65 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.65 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.58 |
| ▸ | MTOR | P42345 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2423268 | 1.00 | PIM1 (0.65) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL2882800 | 0.90 | PIM1 (0.79) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL2882802 | 0.90 | PIM1 (0.79) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL497023 | 0.79 | CLK1 (0.74) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL497022 | 0.79 | CLK1 (0.74) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL497536 | 0.79 | PIM1 (1.00) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL497535 | 0.79 | PIM1 (1.00) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL1249852 | 0.75 | GSK3B (0.60) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL1249857 | 0.75 | GSK3B (0.60) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| Trifluoroacetic Acid SCHEMBL2423801 | 0.75 | PIM1 (0.51) | PIM1PIK3CAPIK3CGCISD1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150051185-A1 | Chemical Compounds 251 | ASTRAZENECA AB (SE) | 2015-02-19 | — | — | US | disclosed |
| US-8901307-B2 | Chemical compounds 251 | ASTRAZENECA AB (SE) | 2014-12-02 | — | — | US | disclosed |
| US-20110218182-A1 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2011-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218182-A1 | CHEMICAL COMPOUNDS 251 | PIM1, PIM3, PIM2 | PIM1 1/4885PIK3CD 483/4885CSNK2A2 322/4885 |
| US-20150051185-A1 | Chemical Compounds 251 | PIM1, PIM3, PIM2 | PIM1 1/4885PIK3CD 507/4885CSNK2A2 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.